The aroma of a freshly baked Cheeseburger Casserole wafting through the kitchen always takes me back to those cherished evenings spent in Mama Lou’s cozy kitchen. With her apron wrapped around her like a comforting hug, she would weave magic with the simplest of ingredients. I remember sitting at the wooden table, my sister Ouma by my side, both of us eagerly waiting to taste the cheesy goodness that epitomized warmth and family. It’s these memories that inspire my cooking today, as I strive to recreate that sense of nostalgia with every dish I serve. Today, I’m thrilled to share a recipe that not only warms the stomach but also the soul, just like Mama Lou’s special dishes used to.
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Why You’ll Love This Cheeseburger Casserole
This Cheeseburger Casserole is a delightful fusion of simplicity and comfort, offering all the flavors of a classic cheeseburger in a warm, hearty dish. It’s perfect for those evenings when you crave something familiar yet effortlessly satisfying. The gooey cheese mingles with seasoned beef and tender pasta, creating a dish that’s both filling and flavorful. For me, it’s a reminder of the family gatherings at Mama Lou’s, where laughter was abundant, and love was the main ingredient. Whether you’re cooking for your family or yourself, this casserole promises to bring a smile to your face and warmth to your heart.
Ingredients You’ll Need for This Cheeseburger Casserole

- 1 pound ground beef
- 1 medium onion, diced
- 2 cloves garlic, minced
- 1 can (15 oz) tomato sauce
- 1 tablespoon Worcestershire sauce
- 1 teaspoon mustard powder
- 2 cups cheddar cheese, shredded
- 2 cups uncooked elbow macaroni
- Salt and pepper to taste
- 1 tablespoon olive oil
- 2 tablespoons ketchup
- 1 teaspoon smoked paprika
If you’re looking to switch things up, you can substitute the ground beef with ground turkey for a lighter version. Mozzarella cheese can be used in place of cheddar for a different flavor profile, while gluten-free pasta makes it a suitable option for those with dietary restrictions.
Nutrition Facts
- Calories: 450 per serving
- Protein: 25g
- Fat: 20g
- Carbohydrates: 40g
- Fiber: 3g
- Sugar: 6g
- Sodium: 720mg

Sizzling Comfort: Dive into the Ultimate Cheeseburger Casserole Experience
Learn how to make delicious Cheeseburger Casserole. Easy recipe with step-by-step instructions.
- Total Time: 45 minutes
- Yield: 4 servings 1x
Ingredients
- 1 pound ground beef
- 1 medium onion, diced
- 2 cloves garlic, minced
- 1 can (15 oz) tomato sauce
- 1 tablespoon Worcestershire sauce
- 1 teaspoon mustard powder
- 2 cups cheddar cheese, shredded
- 2 cups uncooked elbow macaroni
- Salt and pepper to taste
- 1 tablespoon olive oil
- 2 tablespoons ketchup
- 1 teaspoon smoked paprika
If you’re looking to switch things up, you can substitute the ground beef with ground turkey for a lighter version. Mozzarella cheese can be used in place of cheddar for a different flavor profile, while gluten-free pasta makes it a suitable option for those with dietary restrictions.
Instructions
- Preheat your oven to 350°F (175°C). This is the perfect time to reminisce about those family gatherings while you prepare your ingredients.
- In a large skillet, heat olive oil over medium heat. Add the diced onion and minced garlic, sautéing until fragrant and translucent, about 3 minutes. Mama Lou always said that the secret to a good dish is in the aroma of sautéed onions and garlic.
- Add the ground beef to the skillet, cooking until browned. Break it up with a wooden spoon as it cooks, ensuring even browning.
- Stir in the tomato sauce, Worcestershire sauce, mustard powder, ketchup, smoked paprika, and a generous pinch of salt and pepper. Let it simmer for about 5 minutes, allowing the flavors to meld together beautifully.
- While the beef mixture simmers, cook the elbow macaroni according to package instructions until al dente. Drain and set aside.
- In a large mixing bowl, combine the beef mixture with the cooked macaroni. Stir in half of the shredded cheddar cheese, ensuring everything is well combined.
- Transfer the mixture to a greased 9×13 inch baking dish. Top with the remaining cheddar cheese, spreading it evenly over the casserole.
- Bake in the preheated oven for 20-25 minutes, or until the cheese is melted and bubbly. This is where the magic happens, as the flavors meld together to create something truly special.
- Allow the casserole to cool for a few minutes before serving. This gives you a moment to reflect on the joy of sharing a meal with loved ones, much like we did in Mama Lou’s kitchen.
- Prep Time: 15 minutes
- Cook Time: 30 minutes
- Category: Main Dish
- Method: Cooking
- Cuisine: International
Steps to Create Your Cheeseburger Casserole
- Preheat your oven to 350°F (175°C). This is the perfect time to reminisce about those family gatherings while you prepare your ingredients.
- In a large skillet, heat olive oil over medium heat. Add the diced onion and minced garlic, sautéing until fragrant and translucent, about 3 minutes. Mama Lou always said that the secret to a good dish is in the aroma of sautéed onions and garlic.
- Add the ground beef to the skillet, cooking until browned. Break it up with a wooden spoon as it cooks, ensuring even browning.
- Stir in the tomato sauce, Worcestershire sauce, mustard powder, ketchup, smoked paprika, and a generous pinch of salt and pepper. Let it simmer for about 5 minutes, allowing the flavors to meld together beautifully.
- While the beef mixture simmers, cook the elbow macaroni according to package instructions until al dente. Drain and set aside.
- In a large mixing bowl, combine the beef mixture with the cooked macaroni. Stir in half of the shredded cheddar cheese, ensuring everything is well combined.
- Transfer the mixture to a greased 9×13 inch baking dish. Top with the remaining cheddar cheese, spreading it evenly over the casserole.
- Bake in the preheated oven for 20-25 minutes, or until the cheese is melted and bubbly. This is where the magic happens, as the flavors meld together to create something truly special.
- Allow the casserole to cool for a few minutes before serving. This gives you a moment to reflect on the joy of sharing a meal with loved ones, much like we did in Mama Lou’s kitchen.
Tips for Making the Best Cheeseburger Casserole
To make the best Cheeseburger Casserole, ensure your pasta is cooked just right—not too soft, as it will continue to cook in the oven. For an added touch of flavor, consider adding a dash of hot sauce or a sprinkle of red pepper flakes to the beef mixture. Mama Lou always believed in tasting as you go, so don’t hesitate to adjust the seasoning to your liking. Learn more: Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Fusion
Serving Suggestions and Pairings

This Cheeseburger Casserole is a versatile dish that pairs beautifully with a crisp green salad or roasted vegetables, adding freshness to the hearty casserole. For a complete meal, serve it with a side of garlic bread, reminiscent of the warm, crusty bread Mama Lou used to bake. A glass of iced tea or a light red wine complements the casserole perfectly, enhancing the flavors with every bite.
Storage and Reheating Tips
Leftovers, if any, can be stored in an airtight container in the refrigerator for up to 3 days. To reheat, place a portion in the microwave and heat until warmed through, or use the oven for a crispier top. Mama Lou always said that flavors deepen with time, so don’t be surprised if it tastes even better the next day!
Frequently Asked Questions
What are the main ingredients for Cheeseburger Casserole?
The main ingredients for Cheeseburger Casserole include the items listed in our ingredients section above. Each ingredient plays a crucial role in achieving the perfect flavor and texture.
How long does it take to make Cheeseburger Casserole?
The total time to make Cheeseburger Casserole includes both preparation and cooking time. Check the recipe card above for exact timing details.
Can I make Cheeseburger Casserole ahead of time?
Yes, Cheeseburger Casserole can often be prepared in advance. Store it properly in an airtight container in the refrigerator and consume within the recommended timeframe.
What can I serve with Cheeseburger Casserole?
Cheeseburger Casserole pairs well with various sides and accompaniments. Consider the serving suggestions mentioned in the recipe for the best dining experience.
Is Cheeseburger Casserole suitable for special diets?
Depending on the ingredients used, Cheeseburger Casserole may be adapted for various dietary needs. Check the ingredients list and consider substitutions as needed for your dietary requirements.
Final Thoughts
Creating this Cheeseburger Casserole is more than just preparing a meal; it’s about connecting with memories, traditions, and the love that food brings to our lives. Each bite is a reminder of Mama Lou’s kitchen, the laughter shared with Ouma, and the warmth of family. I hope this recipe brings as much joy to your table as it does to mine, becoming a cherished tradition in your home as well.